Green synthesis of bis(indolyl)methanes in water using sulfonic acid functionalized silica (SiO2-Pr-SO3H)
نویسندگان
چکیده مقاله:
Bis(indolyl)methanes are important group of bioactive metabolites of terrestrial and marine regions. They were synthesized by different methods. Herein, a clean, one-pot synthesis of bis(indolyl)methane derivatives by cyclo-condensation reaction of indole and various aldehydes using Sulfonic acid functionalized silica (SiO2-Pr-SO3H) in aqueous media is reported. The advantages of this new method were simple operation, good yields, short reaction times and easy work-up. Sulfonic acid functionalized silica as an efficient heterogeneous solid acid catalyst could be prepared by simple operation from commercially available cheap starting materials such as silica. It catalyzes various organic reactions and could be easily removed, recovered and reused without significant loss of activity.
منابع مشابه
green synthesis of bis(indolyl)methanes in water using sulfonic acid functionalized silica (sio2-pr-so3h)
bis(indolyl)methanes are important group of bioactive metabolites of terrestrial and marine regions. they were synthesized by different methods. herein, a clean, one-pot synthesis of bis(indolyl)methane derivatives by cyclo-condensation reaction of indole and various aldehydes using sulfonic acid functionalized silica (sio2-pr-so3h) in aqueous media is reported. the advantages of this new metho...
متن کاملAn Efficient Green Approach for the Synthesis of Structurally Diversified Spirooxindoles Using Sulfonic Acid Functionalized Nanoporous Silica (SBA-Pr-SO3H)
One-pot multicomponent reaction between isatin, barbituric acid, and 6-amino-1,3-dimethyl uracil was investigated <span style="font-size: 10.0pt; ...
متن کاملApplication of Sulfonic Acid Functionalized Nanoporous Silica (SBA-Pr-SO3H) in the Green One-pot Synthesis of Polyhydroacridine Libraries
1,8-Dioxo-decahydroacridines have been synthesized by the three-component reaction of aromatic aldehydes, aromatic amines (or ammonium acetate), and dimedone in the presence of sulfonic acid functionalized nanoporous silica (SBA-Pr-SO3H) under solvent-free conditions. Excellent yields, short reaction times, mild reaction conditions, an...
متن کاملFacile Knoevenagel condensation Using Sulfonic Acid Functionalized Nanoporous silica (SBA-Pr-SO3H)
Knoevenagel condensation between barbituric acid and aldehyde was investigated in the presence of sulfonic acid functionalized nanoporous silica (SBA-Pr-SO3H) and resulted in the formation of arylidene and bis-arylidene barbiturates. Excellent yields and short reaction times are related to the high efficiency of SBA-Pr-SO3H that the reactions take place easily in its nano-pores. SBA-Pr-SO3H as ...
متن کاملan efficient green approach for the synthesis of structurally diversified spirooxindoles using sulfonic acid functionalized nanoporous silica (sba-pr-so3h)
one-pot multicomponent reaction between isatin, barbituric acid, and 6-amino-1,3-dimethyl uracil was investigated in the presence of sulfonic acid functionalized nanoporous silica (sba-pr-so3h) and resulted in the formation of spirooxindole dipyrimidines. spirooxindole unit is found in many natural products and biologically active molecules and 1,4-dihydropyridines are an important class of com...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 5 شماره 2
صفحات 143- 148
تاریخ انتشار 2015-06-01
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023